Open AccessThe antinociceptive effect of systemic administration of a combination of low-dose tramadol and dexmedetomidine in a rat model of bone cancer pain
Author(s) -
Xiaomin Yuan,
Jingxiang Wu,
Qiong Wang,
Meiying Xu
Publication year - 2014
Publication title -
european journal of anaesthesiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 76
eISSN - 1365-2346
pISSN - 0265-0215
DOI - 10.1097/eja.0b013e3283624a0f
Subject(s) - medicine , tramadol , dexmedetomidine , analgesic , bone cancer , anesthesia , cancer pain , saline , cancer , nociception , incidence (geometry) , sedation , receptor , physics , optics
Multiple factors are involved in the mechanism of bone cancer pain. Treatment with a single drug is not adequate to target all of the different mechanisms.