Open AccessPharmacodynamic modelling of rocuronium in adolescents with Duchenne muscular dystrophy
Author(s) -
Harald Ihmsen,
Vanessa Viethen,
Jürgen Forst,
H. Schwilden,
Schmitt Hj,
Tino Muenster
Publication year - 2009
Publication title -
european journal of anaesthesiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 76
eISSN - 1365-2346
pISSN - 0265-0215
DOI - 10.1097/eja.0b013e32831aed11
Subject(s) - rocuronium , medicine , pharmacokinetics , duchenne muscular dystrophy , pharmacodynamics , propofol , neuromuscular transmission , sufentanil , anesthesia , neuromuscular disease , pharmacology , disease
Studies with rocuronium showed a delayed onset and prolonged recovery in patients with Duchenne muscular dystrophy (DMD). The objective of this study was to identify the pharmacokinetic and/or pharmacodynamic origin of these alterations.