Pharmacodynamic modelling of rocuronium in adolescents with Duchenne muscular dystrophy | Zendy

Harald Ihmsen | Zendy; Vanessa Viethen | Zendy; J. Forst | Zendy; H. Schwilden | Zendy; Hubert J. Schmitt | Zendy; Tino Muenster | Zendy

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Pharmacodynamic modelling of rocuronium in adolescents with Duchenne muscular dystrophy

Author(s) -

Harald Ihmsen,

Vanessa Viethen,

J. Forst,

H. Schwilden,

Hubert J. Schmitt,

Tino Muenster

Publication year - 2009

Publication title -

european journal of anaesthesiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.445

H-Index - 76

eISSN - 1365-2346

pISSN - 0265-0215

DOI - 10.1097/eja.0b013e32831aed11

Subject(s) - rocuronium , medicine , pharmacodynamics , pharmacokinetics , propofol , duchenne muscular dystrophy , neuromuscular transmission , sufentanil , anesthesia , neuromuscular blockade , ed50 , neuromuscular disease , pharmacology , disease , receptor

Studies with rocuronium showed a delayed onset and prolonged recovery in patients with Duchenne muscular dystrophy (DMD). The objective of this study was to identify the pharmacokinetic and/or pharmacodynamic origin of these alterations.

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