Open AccessUrinary neprilysin for early detection of acute kidney injury after cardiac surgery
Author(s) -
Martin H. Bernardi,
Ludwig Wagner,
Sylvia Ryz,
Juergen Puchinger,
Larissa Nixdorf,
Maximilian Edlinger-Stanger,
Johannes Geilen,
Matthias Kainz,
Michael Hiesmayr,
Andrea Lassnigg
Publication year - 2020
Publication title -
european journal of anaesthesiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 76
eISSN - 1365-2346
pISSN - 0265-0215
DOI - 10.1097/eja.0000000000001321
Subject(s) - medicine , interquartile range , acute kidney injury , neprilysin , cardiac surgery , cardiopulmonary bypass , prospective cohort study , creatinine , confidence interval , cardiology , surgery , biochemistry , chemistry , enzyme
Acute kidney injury (AKI) predicts adverse outcomes after cardiac surgery. The accuracy of using changes in serum creatinine for diagnosis and grading of AKI is limited in the peri-operative cardiac surgical setting and AKI may be underdiagnosed due to haemodilution from cardiopulmonary bypass priming and the need for intra-operative and postoperative volume resuscitation.