Open AccessThe effect of oral Δ-9-tetrahydrocannabinol on the minimal alveolar concentration of sevoflurane
Author(s) -
Johannes Müller,
Walter Plöchl,
Birgit Reiter,
Thomas Stimpfl,
Alexandra Gráf,
David M. Baron,
Lukas Infanger,
Thomas Hamp
Publication year - 2020
Publication title -
european journal of anaesthesiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 76
eISSN - 1365-2346
pISSN - 0265-0215
DOI - 10.1097/eja.0000000000001295
Subject(s) - sevoflurane , medicine , minimum alveolar concentration , anesthesia , placebo , confidence interval , analgesic , alternative medicine , pathology
Cannabis has increasingly been used for medical and recreational purposes. The main pharmacological compound in cannabis is tetrahydrocannabinol (THC), which has sedative, anxiolytic and analgesic effects. In some animal models, THC has also been shown to reduce the minimum alveolar concentration (MAC) of halothane and cyclopropane, but its effect on sevoflurane, currently the most commonly used inhalational anaesthetic agent, has not been investigated.