Open AccessFibrinolytic shutdown diagnosed with rotational thromboelastometry represents a moderate form of coagulopathy associated with transfusion requirement and mortality
Author(s) -
Jean-Stéphane David,
Aline Lambert,
Pierre Bouzat,
Pascal Incagnoli,
Anne-Marie Geay-Baillat,
Xavier-Jean Taverna,
Kenji Inaba,
Marc Maegele
Publication year - 2020
Publication title -
european journal of anaesthesiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 76
eISSN - 1365-2346
pISSN - 0265-0215
DOI - 10.1097/eja.0000000000001096
Subject(s) - hyperfibrinolysis , thromboelastometry , medicine , fibrinolysis , shutdown , coagulopathy , odds ratio , tranexamic acid , fibrinogen , confidence interval , anesthesia , surgery , blood loss , nuclear engineering , engineering
Viscoelastic techniques have made it possible to describe specific fibrinolytic phenotypes (physiological, hyperfibrinolysis and shutdown) and to establish a relationship of these phenotypes with outcome. However, there remains a debate as to whether shutdown is a state of hypercoagulability or rather a coagulopathy with moderate fibrinolysis and fibrinogen consumption.