Open AccessTransfusion-related acute lung injury
Author(s) -
Hanane El Kenz,
Philippe Van der Linden
Publication year - 2014
Publication title -
european journal of anaesthesiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 76
eISSN - 1365-2346
pISSN - 0265-0215
DOI - 10.1097/eja.0000000000000015
Subject(s) - medicine , transfusion related acute lung injury , incidence (geometry) , acute respiratory distress , intensive care medicine , diffuse alveolar damage , complication , pathogenesis , blood transfusion , respiratory distress , lung , surgery , pulmonary edema , physics , optics
Transfusion-related acute lung injury (TRALI) is defined as the onset or the worsening of respiratory distress within 6 h of the transfusion of a plasma-containing blood component. It is currently considered to be one of the leading causes of severe posttransfusion morbidity and acute mortality in countries with a high development index. Understanding of the pathogenesis of TRALI has resulted in the development of preventive measures that have contributed to reducing its incidence. Early recognition of the clinical symptoms allow the clinician to identify the syndrome and to undertake therapeutic measures that may reduce the morbidity and mortality associated with this complication.