Open AccessOffspring of Women Exposed In Utero to Diethylstilbestrol (DES)
Author(s) -
Linda Titus-Ernstoff,
Rebecca Troisi,
Elizabeth E. Hatch,
Marianne Hyer,
Lauren A. Wise,
Julie R. Palmer,
Raymond H. Kaufman,
Ervín Adam,
Kenneth L. Noller,
Arthur L. Herbst,
William C. Strohsnitter,
Bernard F. Cole,
Patricia Hartge,
Robert N. Hoover
Publication year - 2008
Publication title -
epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.901
H-Index - 173
eISSN - 1531-5487
pISSN - 1044-3983
DOI - 10.1097/ede.0b013e318163152a
Subject(s) - offspring , diethylstilbestrol , in utero , medicine , incidence (geometry) , pregnancy , obstetrics , cancer , gynecology , infertility , disease , ovarian cancer , physiology , estrogen , fetus , biology , genetics , physics , optics
Animal studies suggest that prenatal exposure to the synthetic estrogen diethylstilbestrol (DES) causes epigenetic changes that may be transmitted to the next generation. Specifically, these studies show an elevated incidence of reproductive tumors in the female offspring of prenatally-exposed mice.