Open AccessA Pharmacoepidemiologic Approach to Evaluate Real-world Effectiveness of Hormonal Contraceptives in the Presence of Drug–drug Interactions
Author(s) -
Amir Sarayani,
Joshua Brown,
Amie Goodin,
Patrick Squires,
Phuong Pham,
Brian Cicali,
Carl Henriksen,
Stephan Schmidt,
Almut G. Winterstein
Publication year - 2020
Publication title -
epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.901
H-Index - 173
eISSN - 1531-5487
pISSN - 1044-3983
DOI - 10.1097/ede.0000000000001302
Subject(s) - medicine , confidence interval , lamotrigine , pregnancy , carbamazepine , oxcarbazepine , levetiracetam , relative risk , concomitant , family planning , pharmacoepidemiology , population , obstetrics , pharmacology , epilepsy , environmental health , psychiatry , biology , medical prescription , genetics , research methodology
Accurate estimation of conception is critical in the assessment of the effects of drugs used during pregnancy or to prevent pregnancy. In a novel application, we studied the effectiveness of oral contraceptives (OCs), where misclassification of conception relative to OC exposure may obscure effect estimates.