Open AccessTopical Aluminum Chloride and Monsel's Solution Block Toluidine Blue Staining in Mohs Frozen Sections: Mechanism and Solution
Author(s) -
Curtis L Chen,
Steven D. Wilson,
Reza Afzalneia,
ChihShan Jason Chen
Publication year - 2019
Publication title -
dermatologic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.659
H-Index - 125
eISSN - 1524-4725
pISSN - 1076-0512
DOI - 10.1097/dss.0000000000001761
Subject(s) - toluidine , staining , chemistry , mohs surgery , prussian blue , chloride , frozen section procedure , nuclear chemistry , pathology , medicine , organic chemistry , electrode , electrochemistry
A diminished-staining artifact is observed in some Mohs frozen sections that are stained in toluidine blue (T-blue). Such an artifact, not yet described in the literature, may interfere with a Mohs surgeon's accurate reading. The authors hypothesize that topical hemostatic agents, aluminum chloride, and Monsel's solution are the causative factors.