Open AccessWeight of Evidence Approach for Skin Sensitization Potency Categorization of Fragrance Ingredients
Author(s) -
Mihwa Na,
D. O’Brien,
M. Lavelle,
Isabelle Lee,
G. Frank Gerberick,
A.M. Api
Publication year - 2022
Publication title -
dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 56
eISSN - 2162-5220
pISSN - 1710-3568
DOI - 10.1097/der.0000000000000854
Subject(s) - local lymph node assay , skin sensitization , potency , sensitization , medicine , dermatology , human skin , toxicology , immunology , in vitro , biochemistry , chemistry , biology , genetics
Reliable human potency data are necessary for conducting quantitative risk assessments, as well as development and validation of new nonanimal methods for skin sensitization assessments. Previously, human skin sensitization potency of fragrance materials was derived primarily from human data or the local lymph node assay.