Open AccessDysregulation and implications of N6-methyladenosine modification in renal cell carcinoma
Author(s) -
Ying Wu,
Shiqiang Zhang,
Chujie Chen,
Jun Pang
Publication year - 2022
Publication title -
current urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.476
H-Index - 13
eISSN - 1661-7657
pISSN - 1661-7649
DOI - 10.1097/cu9.0000000000000135
Subject(s) - renal cell carcinoma , medicine , carcinogenesis , methylation , cancer research , regulator , clear cell renal cell carcinoma , n6 methyladenosine , cancer , methyltransferase , biology , biochemistry , gene
Increasing evidence indicates that N 6 -methyladenosine (m 6 A) methylation modification serves important functions in biological metabolism. Dysregulation of m 6 A regulators is related to the progression of different malignancies, including renal cell carcinoma (RCC). Recent studies have reported preliminary findings on the influence of m 6 A regulator dysregulation on RCC tumorigenesis and development. However, no comprehensive review that integrates and analyzes the roles of m 6 A modification in RCC has been published to date. In this review, we focus on the dysregulation of m 6 A regulators as it relates to RCC tumorigenesis and development, as well as possible applications of m 6 A modification in RCC diagnosis and therapeutics.