Open AccessDoes Preoperative Glycemic Control Restore Immune Defense Against Implant-related Infection in Mice With Diabetes?
Author(s) -
Junqing Lin,
Tengli Huang,
Haifeng Wei,
Bingbo Bao,
Tao Gao,
Xianyou Zheng,
Hongyi Zhu
Publication year - 2021
Publication title -
clinical orthopaedics and related research
Language(s) - English
Resource type - Journals
eISSN - 1528-1132
pISSN - 0009-921X
DOI - 10.1097/corr.0000000000002041
Subject(s) - medicine , glycemic , fructosamine , diabetes mellitus , insulin , type 1 diabetes , type 2 diabetes , surgery , gastroenterology , endocrinology
The presence of Type II diabetes is a well-established risk factor for bone and joint infection, especially in patients with poor glycemic control. However, few studies have investigated the effect of the duration of preoperative glycemic intervention. For patients with poor glycemic control, the effect of the duration of preoperative glycemic intervention remains unknown. Many glycemic biomarkers including hemoglobin A1c (HbA1c), fructosamine, and 1,5-anhydroglucitol have different response rates to glycemic change. It is unclear which biomarker is more closely related to the decrease in infection proportion after preoperative glycemic intervention.