Open AccessIntraosseous Regional Prophylactic Antibiotics Decrease the Risk of Prosthetic Joint Infection in Primary TKA: A Multicenter Study
Author(s) -
Ben Parkinson,
Peter McEwen,
Matthew Wilkinson,
Kaushik Hazratwala,
Jorgen Hellman,
Heng Kan,
Andrew McLean,
Yash Panwar,
Kenji Doma,
Alan Grant
Publication year - 2021
Publication title -
clinical orthopaedics and related research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.178
H-Index - 204
eISSN - 1528-1132
pISSN - 0009-921X
DOI - 10.1097/corr.0000000000001919
Subject(s) - medicine , antibiotics , retrospective cohort study , cohort , demographics , antibiotic prophylaxis , cohort study , surgery , demography , sociology , microbiology and biotechnology , biology
Recent studies have demonstrated that the administration of regional prophylactic antibiotics by intraosseous (IO) injection achieves tissue concentrations around the knee that are 10- to 15-fold higher than intravenous (IV) delivery of prophylactic antibiotics. It is currently unknown whether the use of regional prophylactic antibiotics for primary TKA would result in a lower risk of prosthetic joint infection (PJI).