Open AccessAntibacterial Activity in Iodine-coated Implants Under Conditions of Iodine Loss: Study in a Rat Model Plus In Vitro Analysis
Author(s) -
Ken Ueoka,
Tamon Kabata,
Masaharu Tokoro,
Yoshitomo Kajino,
Dai Inoue,
Tomoharu Takagi,
Takaaki Ohmori,
Junya Yoshitani,
Takuro Ueno,
Yuki Yamamuro,
Atsushi Taninaka,
Hiroyuki Tsuchiya
Publication year - 2021
Publication title -
clinical orthopaedics and related research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.178
H-Index - 204
eISSN - 1528-1132
pISSN - 0009-921X
DOI - 10.1097/corr.0000000000001753
Subject(s) - iodine , in vivo , medicine , in vitro , periprosthetic , implant , antimicrobial , biomedical engineering , plasma electrolytic oxidation , nuclear chemistry , surgery , microbiology and biotechnology , materials science , chemistry , biochemistry , electrolyte , arthroplasty , metallurgy , biology , electrode
We developed iodine-coated titanium implants to suppress microbial activity and prevent periprosthetic joint infection (PJI); their efficacy was demonstrated in animal and in vitro models. The iodine content in iodine-coated implants naturally decreases in vivo. However, to our knowledge, the effect of reduced iodine content on the implant's antimicrobial activity has not been evaluated to date.