Open AccessBupivacaine and Lidocaine Induce Apoptosis in Osteosarcoma Tumor Cells
Author(s) -
Saied Mirshahidi,
Troy G. Shields,
Rosalia de Necochea-Campion,
Xiangpeng Yuan,
Ata Janjua,
Nadine L. Williams,
Hamid Mirshahidi,
Mark E. Reeves,
Penelope J. Duerksen-Hughes,
Lee M. Zuckerman
Publication year - 2020
Publication title -
clinical orthopaedics and related research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.178
H-Index - 204
eISSN - 1528-1132
pISSN - 0009-921X
DOI - 10.1097/corr.0000000000001510
Subject(s) - medicine , lidocaine , bupivacaine , osteosarcoma , apoptosis , anesthesia , local anesthetic , pharmacology , cancer research , biochemistry , chemistry
Osteosarcoma is the most common type of bone cancer in adolescents. There have been no significant improvements in outcomes since chemotherapy was first introduced. Bupivacaine and lidocaine have been shown to be toxic to certain malignancies. This study evaluates the effect of these medications on two osteosarcoma cell lines.