Open AccessPercutaneous CO2 Treatment Accelerates Bone Generation During Distraction Osteogenesis in Rabbits
Author(s) -
Yohei Kumabe,
Tomoaki Fukui,
Shunsuke Takahara,
Yu Kuroiwa,
Michio Arakura,
Keisuke Oe,
Takenori Oda,
Kenichi Sawauchi,
Takehiko Matsushita,
Tomoyuki Matsumoto,
Shinya Hayashi,
Ryosuke Kuroda,
Takahiro Niikura
Publication year - 2020
Publication title -
clinical orthopaedics and related research
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.178
H-Index - 204
eISSN - 1528-1132
pISSN - 0009-921X
DOI - 10.1097/corr.0000000000001288
Subject(s) - distraction osteogenesis , medicine , endochondral ossification , bone healing , angiogenesis , distraction , vascular endothelial growth factor , bone mineral , dentistry , surgery , cartilage , pathology , osteoporosis , anatomy , vegf receptors , neuroscience , biology
Distraction osteogenesis has been broadly used to treat various structural bone deformities and defects. However, prolonged healing time remains a major problem. Various approaches including the use of low-intensity pulsed ultrasound, parathyroid hormone, and bone morphogenetic proteins (BMPs) have been studied to shorten the treatment period with limited success. Our previous studies of rats have reported that the transcutaneous application of CO2 accelerates fracture repair and bone-defect healing in rats by promoting angiogenesis, blood flow, and endochondral ossification. This therapy may also accelerate bone generation during distraction osteogenesis, but, to our knowledge, no study investigating CO2 therapy on distraction osteogenesis has been reported.