Open AccessAdministration of TGF-ß Inhibitor Mitigates Radiation-induced Fibrosis in a Mouse Model
Author(s) -
Itai Gans,
Jad M. El Abiad,
Aaron W. James,
Adam S. Levin,
Carol D. Morris
Publication year - 2020
Publication title -
clinical orthopaedics and related research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.178
H-Index - 204
eISSN - 1528-1132
pISSN - 0009-921X
DOI - 10.1097/corr.0000000000001286
Subject(s) - medicine , fibrosis , transforming growth factor , radiation therapy , intraperitoneal injection , placebo , subcutaneous injection , hindlimb , pathology , alternative medicine
Radiation-induced fibrosis is a long-term adverse effect of external beam radiation therapy for cancer treatment that can cause pain, loss of function, and decreased quality of life. Transforming growth factor beta (TGF-β) is believed to be critical to the development of radiation-induced fibrosis, and TGF-β inhibition decreases the development of fibrosis. However, no treatment exists to prevent radiation-induced fibrosis. Therefore, we aimed to mitigate the development of radiation-induced fibrosis in a mouse model by inhibiting TGF-β.