Open AccessPatterns of Change Over Time in Knee Bone Shape Are Associated with Sex
Author(s) -
Barton L. Wise,
Jingbo Niu,
Yuqing Zhang,
Felix Liu,
Joyce Pang,
John A. Lynch,
Nancy E Lane
Publication year - 2020
Publication title -
clinical orthopaedics and related research
Language(s) - English
Resource type - Journals
eISSN - 1528-1132
pISSN - 0009-921X
DOI - 10.1097/corr.0000000000001219
Subject(s) - medicine , osteoarthritis , cohort , knee pain , radiography , knee joint , cohort study , physical therapy , surgery , pathology , alternative medicine
Knee osteoarthritis (OA) is more common in females than in males; however, the biological mechanisms for the difference in sex in patients with knee OA are not well understood. Knee shape is associated with OA and with sex, but the patterns of change in the bone's shape over time and their relation to sex and OA are unknown and may help inform how sex is associated with shape and OA and whether the effect is exerted early or later in life.Questions/purposes (1) Does knee shape segregate stably into different groups of trajectories of change (groups of knees that share similar patterns of changes in bone shape over time)? (2) Do females and males have different trajectories of bone shape changes? (3) Is radiographic OA at baseline associated with trajectories of bone shape changes?