Open AccessDoes Vitamin D3 Prevent the Inhibitory Effect of Vancomycin on Osteoblasts?
Author(s) -
Kentaro Tsuji,
Soichiro Kimura,
Kazuhiro Tateda,
Hiroshi Takahashi
Publication year - 2019
Publication title -
clinical orthopaedics and related research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.178
H-Index - 204
eISSN - 1528-1132
pISSN - 0009-921X
DOI - 10.1097/corr.0000000000001060
Subject(s) - vancomycin , medicine , osteoblast , vitamin , pharmacology , alkaline phosphatase , in vitro , biochemistry , staphylococcus aureus , chemistry , biology , bacteria , genetics , enzyme
The utility of vancomycin powder to prevent surgical site infection, mainly in spinal surgery, has been widely examined, and the local administration of vancomycin powder to wounds has been reported to be effective in preventing surgical site infections after spine surgery. However, in vitro studies have shown that high local concentrations of vancomycin may inhibit osteogenesis, although it remains unclear how these high concentrations influence osteoblasts. No candidate drug has been reported to recover cytotoxicity with high concentrations of vancomycin, but we suggest that vitamin D3, which induces osteoblast proliferation, may be administrated concomitantly with vancomycin in these situations.