Open AccessCan Dynamic Contrast-Enhanced CT Quantify Perfusion in a Stimulated Muscle of Limited Size? A Rat Model
Author(s) -
John Walker,
Thomas J. Walters,
M. Parker,
Joseph C. Wenke
Publication year - 2019
Publication title -
clinical orthopaedics and related research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.178
H-Index - 204
eISSN - 1528-1132
pISSN - 0009-921X
DOI - 10.1097/corr.0000000000001045
Subject(s) - medicine , perfusion , blood flow , blood volume , stimulation , muscle tissue , tibialis anterior muscle , perfusion scanning , limb perfusion , skeletal muscle , nuclear medicine , biomedical engineering , anatomy , anesthesia , radiology
Muscle injury may result in damage to the vasculature, rendering it unable to meet the metabolic demands of muscle regeneration and healing. Therefore, therapies frequently aim to maintain, restore, or improve blood supply to the injured muscle. Although there are several options to assess the vascular outcomes of these therapies, few are capable of spatially assessing perfusion in large volumes of tissue.