Open AccessWhat Are the Effects of Irreversible Electroporation on a Staphylococcus aureus Rabbit Model of Osteomyelitis?
Author(s) -
Nina M. Muñoz,
A Minhaj,
Crystal Dupuis,
Joe Ensor,
Natalia Golardi,
Jesse Manuel Jaso,
Kathleen Dixon,
Tomás Appleton Figueira,
Jessica Galloway-Peña,
Lori R. Hill,
Samuel A. Shelburne,
Alda L. Tam
Publication year - 2019
Publication title -
clinical orthopaedics and related research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.178
H-Index - 204
eISSN - 1528-1132
pISSN - 0009-921X
DOI - 10.1097/corr.0000000000000882
Subject(s) - cefazolin , osteomyelitis , medicine , electroporation , staphylococcus aureus , in vivo , microbiology and biotechnology , antibiotics , staphylococcal infections , surgery , bacteria , biology , biochemistry , genetics , gene
The treatment of osteomyelitis can be challenging because of poor antibiotic penetration into the infected bone and toxicities associated with prolonged antibiotic regimens to control infection. Irreversible electroporation (IRE), a percutaneous image-guided ablation technology in which the targeted delivery of high-voltage electrical pulses permanently damages the cell membrane, has been shown to effectively control bacterial growth in various settings. However, IRE for the management of bone infections has yet to be evaluated.