Open AccessFailure of Indomethacin and Radiation to Prevent Blast-induced Heterotopic Ossification in a Sprague-Dawley Rat Model
Author(s) -
Astor Robertson,
Alexander Chiaramonti,
Thao P. Nguyen,
David Jaffe,
R. Holmes,
E Lex Hanna,
Juong G. Rhee,
William R. Barfield,
W.L. Fourney,
Joseph P. Stains,
Vincent D. Pellegrini
Publication year - 2018
Publication title -
clinical orthopaedics and related research
Language(s) - English
Resource type - Journals
eISSN - 1528-1132
pISSN - 0009-921X
DOI - 10.1097/corr.0000000000000594
Subject(s) - medicine , heterotopic ossification , surgery , amputation , radiography , injury severity score , anesthesia , poison control , injury prevention , environmental health
Although use of nonsteroidal antiinflammatory drugs and low-dose irradiation has demonstrated efficacy in preventing heterotopic ossification (HO) after THA and surgical treatment of acetabular fractures, these modalities have not been assessed after traumatic blast amputations where HO is a common complication that can arise in the residual limb.