Open AccessExternal Beam Irradiation Preferentially Inhibits the Endochondral Pathway of Fracture Healing: A Rat Model
Author(s) -
Yongren Wu,
Eissa Hanna,
R. Holmes,
Zilan Lin,
Alexander Chiaramonti,
Russell A. Reeves,
D. G. McDonald,
K Vanek,
William R. Barfield,
Haimin Yao,
Vincent D. Pellegrini
Publication year - 2018
Publication title -
clinical orthopaedics and related research
Language(s) - English
Resource type - Journals
eISSN - 1528-1132
pISSN - 0009-921X
DOI - 10.1097/corr.0000000000000395
Subject(s) - medicine , endochondral ossification , bone healing , microbiology and biotechnology , fracture (geology) , rat model , irradiation , biophysics , anatomy , cartilage , composite material , materials science , physics , nuclear physics , biology
External beam irradiation is an accepted treatment for skeletal malignancies. Radiation acts on both cancerous and normal cells and, depending on the balance of these effects, may promote or impair bone healing after pathologic fracture. Previous studies suggest an adverse effect of radiation on endochondral ossification, but the existence of differential effects of radiation on the two distinct bone healing pathways is unknown.