Open AccessMorvan Syndrome
Author(s) -
Elias Abou-Zeid,
Lana Jeradeh Boursoulian,
Walter S. Metzer,
Betül Gündoğdu
Publication year - 2012
Publication title -
journal of clinical neuromuscular disease
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.466
H-Index - 29
eISSN - 1537-1611
pISSN - 1522-0443
DOI - 10.1097/cnd.0b013e31822b1977
Subject(s) - myokymia , medicine , neuromyotonia , hyperhidrosis , thymoma , myoclonus , thymectomy , confusion , dermatology , anesthesia , antibody , myasthenia gravis , pathology , electromyography , immunology , psychiatry , psychoanalysis , psychology
Morvan syndrome is characterized by central, autonomic, and peripheral hyperactivity. Examples of central hyperactivity include confusion, memory problems, hallucinations, insomnia, and myoclonus; examples of autonomic hyperactivity include hyperhidrosis and fluctuations in blood pressure; examples of peripheral hyperreactivity include clinical or electrophysiological evidence of painful cramps, myokymia, and neuromyotonia. We present a typical case of Morvan syndrome and the first detailed review of the clinical and therapeutic literature of all 27 cases from the English language literature. Morvan syndrome is considered to be an autoimmune disorder and antibodies against voltage-gated potassium channels are found in most cases. Oral immunomodulatory therapy, intravenous immunoglobulin, and plasmapharesis may be entertained. Thymoma is found in approximately 50% of cases and thymectomy may be curative as in our particular case.