Open AccessSex disparity of lung cancer risk in non-smokers: a multicenter population-based prospective study based on China National Lung Cancer Screening Program
Author(s) -
Zheng Wu,
Fengwei Tan,
Zhuoyu Yang,
Fei Wang,
Wei Cao,
Chao Qin,
Xuesi Dong,
Yadi Zheng,
Zilin Luo,
Liang Zhao,
Yiwen Yu,
Yongjie Xu,
Jiansong Ren,
Jufang Shi,
Hongda Chen,
Jiang Li,
Wei Tang,
Sipeng Shen,
Ning Wu,
Wanqing Chen,
Ni Li,
Jie He
Publication year - 2022
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000002161
Subject(s) - lung cancer , medicine , hazard ratio , prospective cohort study , confidence interval , cancer , proportional hazards model , population , cohort study , incidence (geometry) , absolute risk reduction , demography , environmental health , physics , sociology , optics
Non-smokers account for a large proportion of lung cancer patients, especially in Asia, but the attention paid to them is limited compared with smokers. In non-smokers, males display a risk for lung cancer incidence distinct from the females-even after excluding the influence of smoking; but the knowledge regarding the factors causing the difference is sparse. Based on a large multicenter prospective cancer screening cohort in China, we aimed to elucidate the interpretable sex differences caused by known factors and provide clues for primary and secondary prevention.