Open AccessCHCHD2 maintains mitochondrial contact site and cristae organizing system stability and protects against mitochondrial dysfunction in an experimental model of Parkinson's disease
Author(s) -
Lin Lü,
Hengxu Mao,
Miaomiao Zhou,
Yuwan Lin,
Wei Dai,
Jingjun Qiu,
Yang Xiao,
Mingshu Mo,
Xiaodong Zhu,
Zhuohua Wu,
Zhong Pei,
Wenyuan Guo,
Pingyi Xu,
Xiang Chen
Publication year - 2022
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000002053
Subject(s) - gene knockdown , mptp , mitochondrion , chemistry , small hairpin rna , microbiology and biotechnology , immunoprecipitation , dopaminergic , biology , apoptosis , biochemistry , neuroscience , gene , dopamine
Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's dementia. Mitochondrial dysfunction is involved in the pathology of PD. Coiled-coil-helix-coiled-coil-helix domain-containing 2 (CHCHD2) was identified as associated with autosomal dominant PD. However, the mechanism of CHCHD2 in PD remains unclear.