Open AccessUpregulation of miR-345-5p suppresses cell growth of lung adenocarcinoma by regulating ras homolog family member A (RhoA) and Rho/Rho associated protein kinase (Rho/ROCK) pathway
Author(s) -
Qing Zhou,
Shuyu Gui,
Peng Zhang,
Mei Wang
Publication year - 2021
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000001804
Subject(s) - rhoa , adenocarcinoma , oncogene , microrna , cancer research , downregulation and upregulation , flow cytometry , apoptosis , cell growth , biology , lung cancer , lung , reverse transcription polymerase chain reaction , cell cycle , microbiology and biotechnology , signal transduction , cancer , medicine , pathology , messenger rna , gene , genetics
Microribose nucleic acids (miRNAs) are implicated in the progression of lung adenocarcinoma. MicroRNA-345-5p (miR-345-5p) is a recently identified anti-oncogene in some human cancers, but its functional role and possible molecular mechanism in lung adenocarcinoma remain unknown. This study aimed to identify the biological function and underlying mechanism of miR-345-5p in lung adenocarcinoma cells.