Open AccessAssociation between circulating CD39+CD8+ T cells pre-chemoradiotherapy and prognosis in patients with nasopharyngeal carcinoma
Author(s) -
Dong D-N.,
Fan P-W.,
Feng Y-N.,
Liu G-H.,
Peng Y-C.,
Tao Dong,
Wang Rz,
Yu Jm
Publication year - 2021
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000001745
Subject(s) - medicine , cd8 , nasopharyngeal carcinoma , chemoradiotherapy , oncology , gastroenterology , metastasis , flow cytometry , cancer , immunology , immune system , radiation therapy
The mortality rate among patients with nasopharyngeal carcinoma (NPC) has improved significantly with the advent of chemoradiotherapy strategies. However, distant metastasis remains problematic. Tumor-specific reactivity in cancer patients has been detected exclusively in CD39+ T cells, particularly in CD39+CD103+ T cells. Circulating cancer-specific T cells are important for protecting against metastasis. This study aimed to evaluate the predictive value of circulating CD39+CD8+ T cells for metastasis in patients with NPC.