Open AccessComputed tomography-identified phenotypes of small airway obstructions in chronic obstructive pulmonary disease
Author(s) -
Tao Li,
Hailang Zhou,
Zekun Zhou,
Liquan Guo,
Lei Zhou
Publication year - 2021
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000001724
Subject(s) - copd , medicine , spirometry , airway , computed tomography , airway obstruction , pulmonary disease , pulmonary function testing , disease , radiology , pathology , surgery , asthma
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characteristic of small airway inflammation, obstruction, and emphysema. It is well known that spirometry alone cannot differentiate each separate component. Computed tomography (CT) is widely used to determine the extent of emphysema and small airway involvement in COPD. Compared with the pulmonary function test, small airway CT phenotypes can accurately reflect disease severity in patients with COPD, which is conducive to improving the prognosis of this disease. CT measurement of central airway morphology has been applied in clinical, epidemiologic, and genetic investigations as an inference of the presence and severity of small airway disease. This review will focus on presenting the current knowledge and methodologies in chest CT that aid in identifying discrete COPD phenotypes.