Open AccessPro-pigmentary action of 5-fluorouracil through the stimulated secretion of CXCL12 by dermal fibroblasts
Author(s) -
Zhi-Kai Liao,
Shuang-Hai Hu,
Bin-Yu Han,
Qiu Xie,
Shan Jiang,
Tiechi Lei
Publication year - 2021
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000001689
Subject(s) - immunostaining , wound healing , staining , fluorouracil , blot , melanocyte , fluorescein isothiocyanate , immunofluorescence , microbiology and biotechnology , pathology , biology , immunohistochemistry , medicine , cancer research , cancer , melanoma , immunology , antibody , biochemistry , physics , quantum mechanics , gene , fluorescence
There is growing evidence that 5-fluorouracil (5-FU) combined with therapeutic trauma can effectively induce skin repigmentation in vitiligo patients who are unresponsive to conventional treatments. Previous studies have mainly focused on identifying the antimitotic activity of 5-FU for the treatment of skin cancer, but few studies have investigated its extra-genotoxic actions favoring melanocyte recruitment.