Open AccessLncRNA AFAP1-AS1/miR-27b-3p/VEGF-C axis modulates stemness characteristics in cervical cancer cells
Author(s) -
Meng Xia,
Lijun Duan,
Bingwei Lu,
Yuzhou Pang,
Zhigang Pang
Publication year - 2021
Publication title -
chinese medical journal/chinese medical journal
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000001665
Subject(s) - cancer research , epithelial–mesenchymal transition , cancer stem cell , gene knockdown , biology , microrna , vascular endothelial growth factor , microbiology and biotechnology , stem cell , chemistry , downregulation and upregulation , cell culture , gene , biochemistry , genetics , vegf receptors
Long non-coding RNA (lncRNA) actin filament-associated protein 1 antisense RNA 1 (AFAP1-AS1) functions as a competing endogenous RNA to regulate target genes expression by sponging microRNAs (miRs) to play cancer-promoting roles in cancer stem cells. However, the regulatory mechanism of AFAP1-AS1 in cervical cancer (CC) stem cells is unknown. The present study aimed to provide a new therapeutic target for the clinical treatment of CC.