Open AccessHippocampus chronic deep brain stimulation induces reversible transcript changes in a macaque model of mesial temporal lobe epilepsy
Author(s) -
Ning Chen,
Jianguo Zhang,
ChunLei Han,
Fangang Meng
Publication year - 2021
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000001644
Subject(s) - hippocampus , epileptogenesis , epilepsy , hippocampal formation , microarray , mesial temporal lobe epilepsy , gene expression , deep brain stimulation , microarray analysis techniques , macaque , biology , neuroscience , temporal lobe , gene , medicine , genetics , disease , parkinson's disease
Deep brain stimulation (DBS) has seizure-suppressing effects but the molecular mechanisms underlying its therapeutic action remain unclear. This study aimed to systematically elucidate the mechanisms underlying DBS-induced seizure suppression at a molecular level.