Open AccessElevated serum Dickkopf-1 is a biomarker for bone erosion in patients with psoriatic arthritis
Author(s) -
Yukchiu Chung,
Zhichang Li,
Xiaolin Sun,
Yanying Li,
Miao Shao,
Yuzhou Gan,
Yimin Li,
Yuhui Li,
Xuewu Zhang
Publication year - 2021
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000001612
Subject(s) - medicine , rheumatoid arthritis , psoriatic arthritis , odds ratio , bone erosion , confidence interval , gastroenterology , psoriasis , arthritis , logistic regression , rheumatoid factor , oncology , immunology
Psoriatic arthritis (PsA) is an inflammatory arthropathy characterized by psoriasis and bone erosion on radiology. Dickkopf-1 (Dkk-1) is considered to be the main inhibitor of the Wnt signaling pathway and results in reduced osteoblast proliferation. The aim of this study was to investigate the serum level of Dkk-1 and its association with bone erosion in PsA patients.