Open AccessMacrophage exosomes transfer angiotensin II type 1 receptor to lung fibroblasts mediating bleomycin-induced pulmonary fibrosis
Author(s) -
Nana Sun,
Yue Zhang,
Wenhui Huang,
Bojun Zheng,
Shuguang Jin,
Xu Li,
Ying Meng
Publication year - 2021
Publication title -
chinese medical journal/chinese medical journal
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000001605
Subject(s) - bleomycin , angiotensin ii , pulmonary fibrosis , microvesicles , fibrosis , lung , cancer research , in vivo , idiopathic pulmonary fibrosis , immunology , chemistry , receptor , medicine , pathology , biology , microrna , biochemistry , microbiology and biotechnology , chemotherapy , gene
Macrophages are involved in the pathogenesis of idiopathic pulmonary fibrosis, partially by activating lung fibroblasts. However, how macrophages communicate with lung fibroblasts is largely unexplored. Exosomes can mediate intercellular communication, whereas its role in lung fibrogenesis is unclear. Here we aim to investigate whether exosomes can mediate the crosstalk between macrophages and lung fibroblasts and subsequently induce fibrosis.