Open AccessInterferon-gamma inhibits aldehyde dehydrogenasebright cancer stem cells in the 4T1 mouse model of breast cancer
Author(s) -
Xiufen Zhuang,
Guangming Shi,
Xiao Hu,
Huiru Wang,
Wen Qin Sun,
Yanhong Wu
Publication year - 2021
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000001558
Subject(s) - cancer stem cell , cancer research , in vivo , cd8 , medicine , cytotoxic t cell , cancer , breast cancer , cancer cell , metastasis , stem cell , cytokine , in vitro , immunology , biology , immune system , biochemistry , genetics , microbiology and biotechnology
Despite improvements in disease diagnosis, treatment, and prognosis, breast cancer is still a leading cause of cancer death for women. Compelling evidence suggests that targeting cancer stem cells (CSCs) have a crucial impact on overcoming the current shortcomings of chemotherapy and radiotherapy. In the present study, we aimed to study the effects of T cells and a critical anti-tumor cytokine, interferon-gamma (IFN-γ), on breast cancer stem cells.