Open AccessTwo factors affecting the success rate of the second non-invasive prenatal screening after initial no-call result: experience from a single tertiary center in China
Author(s) -
Ying Lin,
Dong Liu,
Hang Li,
Chen Luo,
Ping Hu,
Zhengfeng Xu
Publication year - 2021
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000001531
Subject(s) - medicine , fetus , body mass index , pregnancy , fraction (chemistry) , obstetrics , prenatal diagnosis , biology , chemistry , genetics , organic chemistry
One inevitable shortcoming of non-invasive prenatal screening (NIPS)/cell-free DNA (cfDNA) sequencing is the uninterpretable ("no-call") result, which is mainly caused by an insufficient fetal fraction. This study was performed to investigate the factors associated with a successful second NIPS in these cases and determine the optimal management for women with initial no-call results.