Open AccessEffects of HDAC4 on IL-1β-induced matrix metalloproteinase expression regulated partially through the WNT3A/β-catenin pathway
Author(s) -
Qi Ning,
YeHua Gan,
Ruirui Shi,
Juan-Hong Meng
Publication year - 2021
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000001470
Subject(s) - wnt3a , transfection , wnt signaling pathway , gene knockdown , hdac4 , chemistry , blot , downregulation and upregulation , microbiology and biotechnology , small interfering rna , cancer research , signal transduction , cell culture , biology , histone deacetylase , histone , biochemistry , genetics , gene
Histone deacetylase 4 (HDAC4) regulates chondrocyte hypertrophy and bone formation. The aim of the present study was to explore the effects of HDAC4 on Interleukin 1 beta (IL-1β)-induced chondrocyte extracellular matrix degradation and whether it is regulated through the WNT family member 3A (WNT3A)/β-catenin signaling pathway.