Open AccessAnterior thalamic nuclei deep brain stimulation inhibits mossy fiber sprouting via 3′,5′-cyclic adenosine monophosphate/protein kinase A signaling pathway in a chronic epileptic monkey model
Author(s) -
Tingting Du,
Ying Chen,
Guanyu Zhu,
Defeng Liu,
Yu-Ye Liu,
Tianshuo Yuan,
Xin Zhang,
Jianguo Zhang
Publication year - 2021
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000001302
Subject(s) - epilepsy , dentate gyrus , cyclic adenosine monophosphate , deep brain stimulation , kainic acid , medicine , hippocampus , hippocampal formation , neuroscience , stimulation , mossy fiber (hippocampus) , adenosine , endocrinology , biology , receptor , parkinson's disease , glutamate receptor , disease
Anterior thalamic nuclei (ATN) deep brain stimulation (DBS) is an effective method of controlling epilepsy, especially temporal lobe epilepsy. Mossy fiber sprouting (MFS) plays an indispensable role in the pathogenesis and progression of epilepsy, but the effect of ATN-DBS on MFS in the chronic stage of epilepsy and the potential underlying mechanisms are unknown. This study aimed to investigate the effect of ATN-DBS on MFS, as well as potential signaling pathways by a kainic acid (KA)-induced epileptic model.