Open AccessTargeted inhibition of myeloid-derived suppressor cells in the tumor microenvironment by low-dose doxorubicin to improve immune efficacy in murine neuroblastoma
Author(s) -
Weili Xu,
Bibo Shi,
Suolin Li,
Fei Yu,
Lijia Guo,
Meng Li,
Zhigang Hu,
Guixin Li,
Hui Zhou
Publication year - 2020
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000001234
Subject(s) - neuroblastoma , doxorubicin , cancer research , immune system , myeloid derived suppressor cell , suppressor , tumor microenvironment , myeloid , medicine , myeloid cells , biology , tumor cells , immunology , cancer , cell culture , chemotherapy , genetics
High agglomeration of myeloid-derived suppressor cells (MDSCs) in neuroblastoma (NB) impeded therapeutic effects. This study aimed to investigate the role and mechanism of targeted inhibition of MDSCs by low-dose doxorubicin (DOX) to enhance immune efficacy in NB.