Open AccessLong non-coding RNA plasmacytoma variant translocation 1 linked to hypoxia-induced cardiomyocyte injury of H9c2 cells by targeting miR-135a-5p/forkhead box O1 axis
Author(s) -
Jin-Juan Xu,
Weihong Zheng,
Jun Wang,
Yuanyuan Chen
Publication year - 2020
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000001147
Subject(s) - gene knockdown , flow cytometry , pvt1 , hypoxia (environmental) , foxo1 , biology , microbiology and biotechnology , microrna , parp1 , cancer research , rna , apoptosis , gene , chemistry , signal transduction , long non coding rna , polymerase , genetics , poly adp ribose polymerase , protein kinase b , oxygen , organic chemistry
Myocardial infarction occurs due to insufficient (ischemia) blood supply to heart for long time; plasmacytoma variant translocation 1 (PVT1) is a long non-coding RNAs (lncRNAs) involved in the pathogenesis of various diseases, including heart disease; However, few studies have explored its role. The present study evaluated the effects of lncRNA PVT1 on hypoxic rat H9c2 cells.