Open AccessMicroRNAs of bone marrow mesenchymal stem cell-derived exosomes regulate acute myeloid leukemia cell proliferation and apoptosis
Author(s) -
Yan Xu,
Yansi Lin,
Ling Zhang,
Ying Lu,
Yanling Sun,
Zhigang Fang,
Ziyu Li,
Ruifang Fan
Publication year - 2020
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000001138
Subject(s) - microvesicles , cell cycle , microrna , myeloid leukemia , mesenchymal stem cell , cell growth , bone marrow , apoptosis , flow cytometry , cell , stem cell , cancer research , biology , gene knockdown , haematopoiesis , microbiology and biotechnology , immunology , gene , biochemistry , genetics
Acute myeloid leukemia (AML) is a malignant hematological disease, originating from hematopoiesis stem cell differentiation obstruction and clonal proliferation. New reagents or biologicals for the treatment of AML are urgently needed, and exosomes have been identified as candidate biomarkers for disease diagnosis and prognosis. This study aimed to investigate the effects of exosomes from bone marrow mesenchymal stem cells (BMSCs) on AML cells as well as the underlying microRNA (miRNA)-mediated mechanisms.