Open AccessModulatory effect of aquaporin 5 on estrogen-induced epithelial-mesenchymal transition in prostate epithelial cells
Author(s) -
Yu Fan,
Tao Song,
Qiang Wei,
Yue Lü,
TzuJung Lin,
Xiaobing Feng,
Xianding Wang,
Zhongli Huang,
Shijian Feng
Publication year - 2020
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000001132
Subject(s) - estrogen receptor , epithelial–mesenchymal transition , estrogen , vimentin , immunohistochemistry , hyperplasia , prostate , western blot , chemistry , estrogen receptor beta , pathology , endocrinology , medicine , biology , metastasis , cancer , breast cancer , biochemistry , gene
Estrogen is involved in the pathophysiological process of benign prostatic hyperplasia (BPH), in which epithelial-mesenchymal transition (EMT) plays an important role. Upregulation of aquaporin (AQP) 5, which is directly activated by estrogen, has been reported to promote EMT in multiple cells. This study aimed to examine the effects of AQP5 on estrogen-induced EMT in the prostate.