Open AccessGenetic factors related to the widespread dissemination of ST11 extensively drug-resistant carbapenemase-producing Klebsiella pneumoniae strains within hospital
Author(s) -
Daixi Li,
Yao Zhai,
Zhao Zhang,
Yanli Guo,
Zhanwei Wang,
Zilong He,
Songnian Hu,
YuSheng Chen,
Yu Kang,
Zhancheng Gao
Publication year - 2020
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000001101
Subject(s) - klebsiella pneumoniae , biology , plasmid , mobile genetic elements , prophage , transposable element , genetics , genome , gene , microbiology and biotechnology , computational biology , escherichia coli , bacteriophage
Carbapenemase-producing Klebsiella pneumoniae (CP-Kp) poses distinct clinical challenges due to extensively drug resistant (XDR) phenotype, and sequence type (ST) 11 is the most dominant blaKPC-2-bearing CP-Kp clone in China. The purpose of this current retrospective study was to explore the genetic factors associated with the success of XDR CP-Kp ST11 strains circulated in the intensive care unit (ICU) of a Chinese tertiary hospital.