Open AccessDiffusion kurtosis imaging: correlation analysis of quantitative model parameters with molecular features in advanced lung adenocarcinoma
Author(s) -
Peng Qin,
Wei Tang,
Yao Huang,
Ning Wu,
Lin Yang,
Ni Li
Publication year - 2020
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000001074
Subject(s) - adenocarcinoma , effective diffusion coefficient , medicine , magnetic resonance imaging , anaplastic lymphoma kinase , lung cancer , epidermal growth factor receptor , pathology , lung , biopsy , kurtosis , oncology , nuclear medicine , cancer , radiology , statistics , mathematics , malignant pleural effusion
Due to development of magnetic resonance-based functional imaging, it is easier to detect micro-structural alterations of tumor tissues. The aim of this study was to conduct a preliminary evaluation of the correlation of non-Gaussian diffusion kurtosis imaging (DKI) parameters with expression of molecular markers (epidermal growth factor receptor [EGFR]; anaplastic lymphoma kinase [ALK]; Ki-67 protein) in patients with advanced lung adenocarcinoma, using routine diffusion-weighted imaging as the reference standard.