Open AccessDnaJA4 is involved in responses to hyperthermia by regulating the expression of F-actin in HaCaT cells
Author(s) -
Rui-Jiao Liu,
Xueli Niu,
Jinping Yuan,
HongDuo Chen,
Xinghua Gao,
Ruiqun Qi
Publication year - 2020
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000001064
Subject(s) - hacat , hyperthermia , cytoskeleton , actin cytoskeleton , actin , flow cytometry , blot , immunofluorescence , chemistry , microbiology and biotechnology , biology , cell , cell culture , medicine , immunology , biochemistry , antibody , genetics , gene
Hyperthermia in combination with DnaJA4-knockout (KO) obviously affects the anti-viral immunity of HaCaT cells. The mechanisms of this process are not yet fully explored. However, it is known that DnaJA4 interacts with actin cytoskeleton after hyperthermia. Our aim was to investigate the effects of DnaJA4 on F-actin in HaCaT cells following hyperthermia.