Open AccessUnfractionated heparin attenuates endothelial barrier dysfunction via the phosphatidylinositol-3 kinase/serine/threonine kinase/nuclear factor kappa-B pathway
Author(s) -
Shengtian Mu,
Jie Tang,
Jianqi Ma,
Yu Zhong,
Han-Zhe Liu,
Xiaochun Ma,
Zhen Zheng
Publication year - 2020
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000000905
Subject(s) - protein kinase b , medicine , pi3k/akt/mtor pathway , lipopolysaccharide , tumor necrosis factor alpha , pharmacology , immunology , endocrinology , chemistry , phosphorylation , signal transduction , biochemistry
Vascular endothelial dysfunction is considered a key pathophysiologic process for the development of acute lung injury. In this study, we aimed at investigating the effects of unfractionated heparin (UFH) on the lipopolysaccharide (LPS)-induced changes of vascular endothelial-cadherin (VE-cadherin) and the potential underlying mechanisms.