Open AccessZinc finger and BTB domain-containing protein 46 is essential for survival and proliferation of acute myeloid leukemia cell line but dispensable for normal hematopoiesis
Author(s) -
Yuan-Yuan Liu,
Feifei Xiao,
Bi-Jie Yang,
Xi Li,
Shuangnian Xu,
Zhiwei Chen,
Ping Li,
Yongxiu Huang,
Xuemei Fu,
Xingqin Huang,
Guangling Zheng,
Jieping Chen,
Yu Hou
Publication year - 2020
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000000878
Subject(s) - haematopoiesis , myeloid leukemia , progenitor cell , flow cytometry , biology , myeloid , bone marrow , microbiology and biotechnology , stem cell , cancer research , cell culture , cell growth , immunology , biochemistry , genetics
Zinc finger and BTB domain-containing protein 46 (Zbtb46) is a transcription factor identified in classical dendritic cells, and maintains dendritic cell quiescence in a steady state. Zbtb46 has been reported to be a negative indicator of acute myeloid leukemia (AML). We found that Zbtb46 was expressed at a relatively higher level in hematopoietic stem and progenitor cells (HSPCs) compared to mature cells, and higher in AML cells compared to normal bone marrow (BM) cells. However, the role of Zbtb46 in HSPCs and AML cells remains unclear. Therefore, we sought to elucidate the effect of Zbtb46 in normal hematopoiesis and AML cells.