Open AccessMicroRNA-145 suppresses uveal melanoma angiogenesis and growth by targeting neuroblastoma RAS viral oncogene homolog and vascular endothelial growth factor
Author(s) -
Jingyan Yang,
Yang Li,
Qian Wang,
WeiZhen Zhou,
Yan-Ni Yan,
Wenbin Wei
Publication year - 2020
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000000875
Subject(s) - angiogenesis , oncogene , cancer research , microrna , biology , vascular endothelial growth factor , cell growth , vascular endothelial growth factor a , neuroblastoma , cancer , cell culture , gene , cell cycle , genetics , vegf receptors
Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. It has been demonstrated that microRNA-145 (miR-145) is correlated with the progression of various cancers by regulating the expression of multiple target genes, especially a number of genes that regulate angiogenesis and proliferation. However, the underlying mechanisms of miR-145 in tumor angiogenesis of UM are still not well illustrated. Thus, we aimed to explore the potential target genes or pathways regulated by miR-145 in UM and the effect of miR-145 on invasion and angiogenesis.