Open AccessSmall airway immunoglobulin A profile in emphysema-predominant chronic obstructive pulmonary disease
Author(s) -
Hu Liu,
Huo-Yan Tang,
JunFa Xu,
Zhigang Pang
Publication year - 2020
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000000863
Subject(s) - copd , medicine , airway , lung , respiratory disease , bronchiolitis , gastroenterology , antibody , immunoglobulin a , immunohistochemistry , pathology , immunology , respiratory system , immunoglobulin g , surgery
Due to airway remodeling and emphysematous destruction in the lung, the two classical clinical phenotypes of chronic obstructive pulmonary disease (COPD) are emphysema and bronchiolitis. The present study was designed to investigate the levels of small airway immunoglobulin A (IgA) in COPD with "emphysema phenotype." The study also evaluated the associations between the small airway IgA levels and the severity of disease by the extent of emphysema versus airflow limitation.