Open AccessSmall molecule proteomics quantifies differences between normal and fibrotic pulmonary extracellular matrices
Author(s) -
Xinlong Wan,
Zhiliang Zhou,
Peng Wang,
Xiaoming Zhou,
Mengying Xie,
Jin Mei,
Jie Weng,
Xi Shan Hao,
Chan Chen,
Zhiyi Wang,
Zhibin Wang
Publication year - 2020
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000000754
Subject(s) - extracellular matrix , saline , lung , extracellular , proteomics , fibrosis , chemistry , biology , pathology , biochemistry , medicine , endocrinology , gene
Pulmonary fibrosis is a respiratory disease caused by the proliferation of fibroblasts and accumulation of the extracellular matrix (ECM). It is known that the lung ECM is mainly composed of a three-dimensional fiber mesh filled with various high-molecular-weight proteins. However, the small-molecular-weight proteins in the lung ECM and their differences between normal and fibrotic lung ECM are largely unknown.